The Fame/C-Edition version of PSPUAE is applied to the processor emulation Fame/C, a C implemented, widely platform independent emulation of the m68k CPU.
The PSPUAE Fame/C-Edition runs faster than the usual PSPUAE, but is a lot more instable and savestates of the Fame/C-Edition are not compatible with the normal PSPUAE version. A further development of PSPUAE Fame/C is for the moment not planned.
Surely FOL can give us some more details.
Homepage can be found as usual here.