MorphOS2 should run. There is also a version of E-UAE for OS4 so if you wanted to run amiga software that is the other option. Most of the later games will run but no WHDLoad (unless in eUAE). TBH IMO i cannot see any reason to but the SAM other than as something to play around with but then if you want to do that get a BPPC and run OS4 classic. It won't be as fast but it'll be more versatile.