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Yes it would run fine on your system specs. You would probably need to run the game in 1024x768 resolution, because I need to do this on my system which is using a 7800GT, but I also have all of the texture settings set to high and have so far not suffered from any lag. If I increased the resolution to 1280x1024 I fully expect I would start to see some lag, but in all honesty I am prepared to reduce the resolution slightly for a better gameplay experience. The graphics might not be quite as crisp as it isn't my monitors native resolution, but it still looks good.
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Grand. I've heard good things about this game. Might pick up Gears of War as well while I'm at it, just to see what the fuss is about (see? I don't need a 360 to play all of its biggest games!).